Patients with systemic inflammatory and autoimmune diseases are at risk of vaccine-preventable illnesses

Patients with systemic inflammatory and autoimmune diseases are at risk of vaccine-preventable illnesses.

OBJECTIVE To evaluate vaccine coverage and humoral immunity to tetanus, diphtheria and poliomyelitis in adults followed for systemic inflammatory and/or autoimmune diseases (SIADs). METHODS A cross-sectional study was conducted between June and August 2006 in a monocentric cohort of adults with SIAD. A standardized questionnaire was administered to collect medical, therapeutic and vaccine cov...

Cancer Risk in Patients With Inflammatory Systemic Autoimmune Rheumatic Diseases

The aim of this study was to determine whether inflammation is related to cancer development, and whether the incidence of cancer is increased and occurs in a site-specific manner in patients with systemic autoimmune rheumatic diseases (SARDs).This study included a nationwide dynamic cohort of patients with various newly diagnosed SARDs from 1997 to 2010 with follow-up until 2012.This study inc...

Role of Interleukin-37 in Inflammatory and Autoimmune Diseases

Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated pr...

Vaccine-preventable diseases.

The panel addressed four main areas of vaccine development and use: diseases of public health importance for which no vaccine is available; diseases for which an existing licensed vaccine is not optimal and alternative vaccines are under development; diseases for which a vaccine exists but is not being used optimally; and diseases requiring vaccines of specialized or limited use, such as those ...

Immunisation and Vaccine Preventable Diseases